Amitriptyline Hcl (Amitriptyline Hcl)
Overview of Amitriptyline Hcl
Amitriptyline Hcl is a prototype drug of tricyclic antidepressants. It has characteristic three ring nucleus. Tricyclic antidepressant has been used for almost four decades. Chemically Amitriptyline Hcl is closely related to the phenothiazines.it also has sedative and anxiolytic properties.
Indication of Amitriptyline Hcl
Amitriptyline Hcl is primarily indicated in conditions like Chronic pain, Depression, Enuresis, Migraine prophylaxis, Tension headache.
Contraindication of Amitriptyline Hcl
Amitriptyline (HCl) is contraindicated in conditions like Glucoma,Myocardial infarction,Prostatic hypertrophy.
Side Effects of Amitriptyline Hcl
The severe or irreversible adverse effects of Amitriptyline (HCl), which give rise to further complications include Postural hypotension, Tachycardia, Cardiac arrhythmias, Conduction disturbances, Congestive heart failure.,Amitriptyline (HCl) produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia. which are responsible for the discontinuation of Amitriptyline (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Amitriptyline (HCl) include Hypotension, Cardiac arrhythmias, Coma, Seizures, Blurred vision, Dry mouth, Urinary retention, Hypothermia, Metabolic acidosis, Mydriasis, Sinus tachycardia, Hypoxia, QT interval lengthening, P-R interval lengthening.,The symptomatic adverse reactions produced by Amitriptyline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Fatigue, Constipation, Dry mouth, Blurred vision, Urinary retensionX, Tremor.
Precautions of Amitriptyline Hcl
Amitriptyline (HCl) should be used with caution in patients with cardiac disease and pre-existing hematological disorders. It is classified as a pregnancy category C drug. No complete or well-controlled studies have been done. Use during pregnancy should be avoided unless the potential benefits outweigh the possible risks to the fetus. Abrupt discontinuation should be avoided because it could precipitate sympotoms of cholinergic rebound such as nausea, vomiting or diarrhoea. It should be used with caution in patients with history of alcoholism or who may use sedative medicines because the depressant effect on CNS can be potentiated.