Diltiazem Hcl (Diltiazem Hcl)
Overview of Diltiazem Hcl
Diltiazem is an anti-arrhythmic agent. Diltiazem Hcl is a calcium channel blocking agent. It lowers the blood pressure by blocking calcium and relaxes the heart muscle and dilates the heart blood vessels. It has been known since the late 1800s that calcium influx was necessary for the contraction of muscle. The discovery of these channels also made possible the developemnet of clinically useful blocking drugs.
Indication of Diltiazem Hcl
Diltiazem Hcl is primarily indicated in conditions like Atrial fibrillation, Cardiac arrhythmia, Coronary artery spasm, Hypertension, Migraine, Moderate to severe reflux oesophagitis, Myocardial infarction, Oesophageal motility disorders, Pulmonary hypertension, Raynaud's phenomenon, Stable angina pectoris, Unstable angina.
Contraindication of Diltiazem Hcl
Diltiazem (HCl) is contraindicated in conditions like Bradycardia,Sick sinus syndrome,Av block of ii &iii degree.
Side Effects of Diltiazem Hcl
The severe or irreversible adverse effects of Diltiazem (HCl), which give rise to further complications include Heart block, Hypoglycemia, GI hemorrhage.,Diltiazem (HCl) produces potentially life-threatening effects which include Paralytic ileus, Pedal edema, Impaired left vntricular function, Facial flushing, Sinus arrest, Facial flushing, Acute hepatic injury, Atrioventricular conduction disturbances. which are responsible for the discontinuation of Diltiazem (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Diltiazem (HCl) include Hypotension, Junctional bradycardia, Low cardiac output.,The symptomatic adverse reactions produced by Diltiazem (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Fever, Constipation, Insomnia, Skin rashes, Peripheral edema, Bradycardia, GI upset, Hypotension, Weight gain, Flushing, Asthenia, Swelling, AV Block, Sore throat, Skin rashes, dizziness, Fainting.
Precautions of Diltiazem Hcl
Diltiazem should be used with caution in patients with kidney or liver impairment, vetricular dysfunction, severe bradycardia, cardiogenic shock or congestive heart failure, sinoatrial nodal dysfunction. Consider decrease in dose of calcium channel blockers and monitor drug response in cirrhosis patients. Diltiazem should not be used in patient with acute myocardial infarction. It is classified as pregnancy category C and should be used during pregnancy with caution only when the benefit outweighs the risk to fetus.