Amikacin sulphate (Amikacin sulphate)
Overview of Amikacin sulphate
The antimicrobial agents or antibiotics develops during the last 60 years are among the most dramatic examples of the advances of science. The remarkably powerful and specific activity of antimicrobial drug is due to the their selectivity for highly specific targets that are either unique to micro-organism or much more important in them than in humans. Amikacin is a semi-synthetic derivative of kanamycin. It belongs to aminoglycoside antibiotic and Amikacin (Sulphate) is less toxic than parent drug, kanamycin. The aminoglycosides are the compound containing characteristic amino sugars joined to a hexose nucleus in glycoside linkage and their polarity accounts for their pharmakokinetic peoperties. Antibiotics require constant drug level in body for therapeutic effect. This is achieve by taking the medication at regular intervel of time throughout the day and night as prescribed. Amikacin (Sulphate) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Indication of Amikacin sulphate
Amikacin Sulphate is primarily indicated in conditions like Burns, Cholangitis, Endometritis, Heart failure, Infectons in neutropenic patients, Meningitis, Mycobacterial infection, Neonatal infections, Peritonitis, Respiratory tract infections, Supraventricular arrhythmias (particularly atrial fibrillation), Urinary tract infection.
Contraindication of Amikacin sulphate
No data regarding the contra indications of Amikacin (Sulphate) is available.
Side Effects of Amikacin sulphate
The severe or irreversible adverse effects of Amikacin (Sulphate), which give rise to further complications include Nephrotoxicity, Neuromuscular blockage, Renal tubular acidosis.,The signs and symptoms that are produced after the acute overdosage of Amikacin (Sulphate) include 8th nerve damage.,The symptomatic adverse reactions produced by Amikacin (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Ataxia, Tinnitus, Sense of fulness in ears, Ototoxicity, Circumoral paresthesia, Pyuria, Proteinuria, Azotemia.
Precautions of Amikacin sulphate
Amikacin should be used with caution in patients with history of kidney diseases, vertigo, hearing loss, mysthenia gravis, parkinsonisms. Use with caution in patients who are sensitive to aminoglycosides. Keep patients well hydrated to prevent chemical irritation or nephrotoxic reactions. Take appropriate measures in case of secondary infections.