Acetazolamide Na (Acetazolamide Na)
Overview of Acetazolamide Na
Acetazolamide (Na) is a prototype carbonic anhydrase inhibitor. Acetazolamide (Na) is a non-bacteriostatic sulfonamide possessing a chemical structure and pharmacological activity distinctly diffrent from the bacteriostatic sulfonamides. The sulfonamide group is essential for the activity of acetazolamide. Carbonic anhydrase inhibitors were the forerunners of the modern diuretics. They are unsubstituted sulfonamide derivative and were developed when it was noted that bacteriostatic sulfonamide caused a alkaline diuresis. With the development of newer agent, the carbonic anhydrase inhibitors are now rarely used. It decreases activity of the nerves in the brain which make it useful as an anticonvulsant drug in the treatment of certain seizure disorders such as epilepsy.
Indication of Acetazolamide Na
Acetazolamide Na is primarily indicated in conditions like Edema, Epilepsy, Fluid retention, Glucoma, Oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Mountain sickness, Periodic paralysis.
Contraindication of Acetazolamide Na
Acetazolamide (Na) is contraindicated in conditions like Renal hyperchloremic acidosis,Addison's disease,Liver diseases,Close-angle glaucoma,Hepatic encephalopathy,Kidney disease.
Side Effects of Acetazolamide Na
The severe or irreversible adverse effects of Acetazolamide (Na), which give rise to further complications include Growth retardation.,Acetazolamide (Na) produces potentially life-threatening effects which include Blood disorders, Skin toxicity, Urinary stone formation, Aplastic Anemia, Stevens Johnson syndrome, Stevens Johnson syndrome, Potassium loss, Aplastic anemia, Metabolic acidosis. which are responsible for the discontinuation of Acetazolamide (Na) therapy.,The signs and symptoms that are produced after the acute overdosage of Acetazolamide (Na) include Disorientation, Drowsiness, Drowsiness.,The symptomatic adverse reactions produced by Acetazolamide (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Thirst, Headache, Drowsiness, Fatigue, Irritability, Excitement, Ataxia, Hyperpnea, Fever, Rashes, GI upset, Flushing, Paresthesias, Hyperphosphatemia, dizziness, bone marrow depression, bone marrow depression.
Precautions of Acetazolamide Na
Use with caution in patients with severe respiratory acidosis or pulmonary obstruction. Balanced electrolyte intake is essential in all patients whose clinical condition may cause electrolyte imbalance. Sensitvity to Surphoramide