Acebutolol (Acebutolol)
Overview of Acebutolol
Acebutolol is a moderately ß1-selective adrenoceptor antagonist with intrinsic sympathomimetic activity, first synthesized in 1967. Acebutolol is prepared by chemical synthesis and the racemate is used clinically. It lowers the blood pressure and slows the heart rate. Acebutolol is available for both oral and intravenous use and as an oral combination product with hydrochlorothiazide. Drugs that blocks the ß1 receptor have been developed to eliminate the unwanted bronchoconstrictor effects (ß2) of propranolol seen among the asthmatic patients. It antagonize ß1 receptors at doses 50 to 100 times less than those required to block ß2 receptors. This cardioselectivty is more pronounced at low doses and is lost at high doses.
Indication of Acebutolol
Acebutolol is primarily indicated in conditions like Angina, Angina pectoris, Cardiac arrhythmia, Hypertension, To prevent recurrence of neural tube defect, and can also be given in adjunctive therapy as an alternative drug of choice in Hypertension in pregnancy, Hypertrophic cardiomyopathy, Migraine, Schizophrenia, Thyrotoxicosis.
Contraindication of Acebutolol
Acebutolol is contraindicated in conditions like Cardiogenic shock,Bronchospasm,Bradycardia.
Side Effects of Acebutolol
Acebutolol produces potentially life-threatening effects which include Severe bradycardia, Severe bronchospasm, Severe hypoglycemia, Severe angina on withdrawal, Severe MI on withdrawal. which are responsible for the discontinuation of Acebutolol therapy.,The signs and symptoms that are produced after the acute overdosage of Acebutolol include Bradycardia, Hypotension, Death.,The symptomatic adverse reactions produced by Acebutolol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tiredness.
Precautions of Acebutolol
Acebutolol should be use with caution in diabetic patients or patients with impaired liver or kidney function.