Ceftaroline fosamil (Ceftaroline fosamil)
Overview of Ceftaroline fosamil
Ceftaroline fosamil is broad-spectrum, prodrug antibacterial of cephalosporin class of beta-lactams (ß-lactams). Chemically, the prodrug, ceftaroline fosamil monoacetate monohydrate is (6R,7R)-7-{(2Z)-2-(ethoxyimino)-2-[5- (phosphonoamino)-1,2,4 thiadiazol-3-yl]acetamido}-3-{[4-(1- methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl}8-oxo-5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate monoacetate monohydrate. The empirical formula is C22H21N8O8PS4•C2H4O2•H2O.
Indication of Ceftaroline fosamil
Ceftaroline fosamil is primarily indicated in conditions like Bacterial skin infections, Community acquired pneumonia.
Contraindication of Ceftaroline fosamil
Ceftaroline fosamil is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects of Ceftaroline fosamil
The severe or irreversible adverse effects of Ceftaroline fosamil, which give rise to further complications include Hepatitis, Renal failure, Hypersensitivity.,The symptomatic adverse reactions produced by Ceftaroline fosamil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Vomiting, Diarrhea, Palpitation, Tachycardia, Constipation, Abdominal pain, Rashes, Urticaria, Thrombocytopenia, Neutropenia, Pyrexia, Anemia, Convulsions, Hepatitis, Hyperglycemia, Anaphylaxis, esinophilia, hyperkalemia.
Precautions of Ceftaroline fosamil
Exercise caution in patients with known hypersensitivity to beta-lactam antibiotics. Clostridium difficile-associated diarrhea (CDAD) has been reported with nearly all systemic antibacterial agents, including Ceftaroline fosamil. Evaluate if diarrhea occurs. If anemia develops during or after therapy, a diagnostic workup for drug-induced hemolytic anemia should be performed and consideration given to its discontinuation . Use with caution in nursing mother.