Dabigatran (Dabigatran)
Overview of Dabigatran
Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Because thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Both free and clot-bound thrombin, and thrombin-induced platelet aggregation are inhibited by the active moieties. This lowers the chances of blood clots formation in body and hence reduces the risk of stroke and blood clots in people with Atrial fibrillation.
Indication of Dabigatran
Dabigatran is primarily indicated in conditions like Stroke, Thromboembolism.
Contraindication of Dabigatran
Dabigatran is contraindicated in conditions like Bleeding,Hypersensitivity to any component of product.
Side Effects of Dabigatran
The severe or irreversible adverse effects of Dabigatran, which give rise to further complications include Bleeding.,Dabigatran produces potentially life-threatening effects which include Bleeding. which are responsible for the discontinuation of Dabigatran therapy.,The signs and symptoms that are produced after the acute overdosage of Dabigatran include hemorrhagic complications.,The symptomatic adverse reactions produced by Dabigatran are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Anaphylactoid reactions, Abdominal pain, Rashes, Urticaria, Pruritus, Epigastric discomfort, Dyspepsia, Faintness, Hypersensitivity reactions, Chest pain, Esophagitis, Wheezing, Chest tightness, Bleeding, GI ulceration, Swelling of face, Difficulty breathing, Swelling of lips and tongue.
Precautions of Dabigatran
Increase risk of bleeding. Renal function should be assessed by calculating creatinine clearance prior to initiation of treatment with Dabigatran.