Desmopressin acetate (Desmopressin acetate)
Overview of Desmopressin acetate
Desmopressin is a long acting synthetic analog of 8-arginine vasopressin. It has an anti-diuretic to pressor ratio 4000 times than that of vasopressin, which is the pressor and antidiuretic principle of posterior lobe of pituitary gland. Desmopressin (Acetate) is used intranasally in diabetes insipidus and nocturnal enuresis.
Indication of Desmopressin acetate
Desmopressin Acetate is primarily indicated in conditions like Diabetes insipidus, Haemophilia, Nocturnal enuresis, Post-lumbar puncture headache, Primary nocturnal enuresis, Renal function testing, Von willebrand's disease, and can also be given in adjunctive therapy as an alternative drug of choice in Nocturia associated with multiple sclerosis, Polydipsia.
Contraindication of Desmopressin acetate
Desmopressin (Acetate) is contraindicated in conditions like Hypertension,Renal diseases,Cardiovascular disease.
Side Effects of Desmopressin acetate
The severe or irreversible adverse effects of Desmopressin (Acetate), which give rise to further complications include Cerebral & Coronary thrombosis.,Desmopressin (Acetate) produces potentially life-threatening effects which include Hyponatremia, Hyponatremia. which are responsible for the discontinuation of Desmopressin (Acetate) therapy.,The signs and symptoms that are produced after the acute overdosage of Desmopressin (Acetate) include Seizures, Hypotonic hyponatremia.,The symptomatic adverse reactions produced by Desmopressin (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Abdominal cramps, Maculopapular rash, Flushing, Nasal congestion, Rhinitis.
Precautions of Desmopressin acetate
Desmopressin should be used with caution in patients with any blood clotting disorders (hemophilia or von Willebrands disease), cystic fibrosis, heart disease or any allergies. It should be used with caution during pregnancy. This medication must be used with caution in children and elderly patients since they may be more sensitive to its effects.