Cinitapride (Cinitapride)
Overview of Cinitapride
Cinitapride is a new prokinetic agent. It is a substituted benzamide with 5-HT receptor antagonist and 5-HT- receptor agonist activity. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.
Indication of Cinitapride
Cinitapride is primarily indicated in conditions like Constipation, Delayed gastric emptying, Gastro-esophageal reflux disease, Non-ulcer dyspepsia.
Contraindication of Cinitapride
Cinitapride is contraindicated in conditions like Hypersensitivity to the drug,Hypersensitivity to any component of product.
Side Effects of Cinitapride
The severe or irreversible adverse effects of Cinitapride, which give rise to further complications include Angioedema, Gynacomastia, Angioedema.,The signs and symptoms that are produced after the acute overdosage of Cinitapride include Drowsiness, Drowsiness, Confusion, Extrapyramidal effects.,The symptomatic adverse reactions produced by Cinitapride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Diarrhea, Sedation, Extra pyramidal symptoms.
Precautions of Cinitapride
Used with caution especially in the elderly because it enhances the action of acetylcholine. It should not be used in patients in whom an increase in gastrointestinal motility could be harmful, e.g. in patients with gastrointestinal hemorrhage, mechanical obstruction or perforation. Used with caution in patients with a history of dyskinesia induced by neuroleptics. Drowsiness may occur with the use of cinitapride and hence caution is to be exercised while driving and using machines. Do not take with alcohol since increased sedation may occur.