Methylergonovine (Methylergonovine)
Overview of Methylergonovine
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus.
Indication of Methylergonovine
Methylergonovine is primarily indicated in conditions like Postpartum haemorrhage.
Contraindication of Methylergonovine
Methylergonovine is contraindicated in conditions like Hypertension,Toxaemia of pregnancy,Hypersensitivity,Pregnancy.
Side Effects of Methylergonovine
The severe or irreversible adverse effects of Methylergonovine, which give rise to further complications include Hallucinations, Hallucinations, Severe allergic reaction, Blood in the urine.,Methylergonovine produces potentially life-threatening effects which include Coma, Seizures. which are responsible for the discontinuation of Methylergonovine therapy.,The signs and symptoms that are produced after the acute overdosage of Methylergonovine include Diarrhea, Hematuria, Confusion, Hallucinations, Palpitations, Dizziness, Hypertension, Tinnitus, Tinnitus, Dyspnea, Myocardial infarction.,The symptomatic adverse reactions produced by Methylergonovine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Abdominal pain, Hypotension, Nausea and vomiting, Seizures, dizziness.
Precautions of Methylergonovine
This drug should not be administered I.V. routinely because of the possibility of inducing sudden hypertensive and cerebrovascular accidents. Caution should be exercised in the presence of sepsis, obliterative vascular disease, hepatic or renal involvement. Also use with caution during the second stage of labor. The necessity for manual removal of a retained placenta should occur only rarely with proper technique and adequate allowance of time for its spontaneous separation.