Disodium Pamidronate (Disodium Pamidronate)
Overview of Disodium Pamidronate
Disodium Pamidronate is a bisphosphonate, inhibits bone resorption and thus reduces bone turn over. Disodium Pamidronate is used in the treatment of bone disorders in which excessive bone resorption is a problem, such as paget`s disease of bone and osteoporosis. Disodium Pamidronate is also used as an adjunct insevere hypercalcaemic conditions especially associated with malignancies.
Indication of Disodium Pamidronate
Disodium Pamidronate is primarily indicated in conditions like Hypercalcaemia due to malignancy, Hypercalcaemia of malignancy, Osteolytic bone metastases, Osteolytic lesions and bone pain, Paget's disease of bone, Sedation with amnesia.
Contraindication of Disodium Pamidronate
Disodium Pamidronate is contraindicated in conditions like Pregnancy,Breast feeding.
Side Effects of Disodium Pamidronate
The symptomatic adverse reactions produced by Disodium Pamidronate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Anorexia, Diarrhea, Fever, Myalgia, Constipation, Insomnia, Abdominal pain, Rashes, Confusion, Pruritus, Lethargy, Hallucination, Dyspepsia, Malaise, Hypotension, Somnolence, Flushing, Arthralgia, Nausea and vomiting, Muscle cramps, Influenza like syndrome, Agitation, Conjunctivitis, Rigors, Seizures, Transient rise in body temperature, Transient bone pain, Local reaction at injection site, Confusion, dizziness, dyspepsia, Thrombophili.
Precautions of Disodium Pamidronate
Disodium Pamidronate should be used with caution in patients with cardiac desease with renal impairment---monitor renal function in renal disease or predisposition to renal impairment (e.g in multiple myeloma or tumor induced hypercalcaemia); cardiac disease (especially in elderly); previous thyroid surgery (risk of hypocalcaemia); monitor serum electrolyte, calcium and phosphate---possibility of convulsions due to electrolyte changes; avoid concurrent use with other bisphosphonate. DRIVING: Patients should be warned against driving or operating machinery immediately after treatment (somnolence or dizziness may occur)