Disodium Etidronate (Disodium Etidronate)
Overview of Disodium Etidronate
Disodium Etidronate is a bisphosphonate, inhibits bone resorption and thus reduces bone turn over. Disodium Etidronate is used in the treatment of bone disorders in which excessive bone resorption is a problem, such as paget`s disease of bone and osteoporosis. Disodium Etidronate is also used as an adjunct insevere hypercalcaemic conditions especially associated with malignancies.
Indication of Disodium Etidronate
Disodium Etidronate is primarily indicated in conditions like Osteoporosis, Paget's disease of bone, Sedation with amnesia, Severe hypercalcaemia.
Contraindication of Disodium Etidronate
Disodium Etidronate is contraindicated in conditions like Pregnancy,Breast feeding,Pain and inflammation (rheumatic disease),Vasomotor symptoms in estrogen deficiency, see instruction.
Side Effects of Disodium Etidronate
The symptomatic adverse reactions produced by Disodium Etidronate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Diarrhea, Skin reactions, Constipation, Abdominal pain, Urticaria, Pruritus, Increased bone pain in paget`s disease.
Precautions of Disodium Etidronate
Disodium Etidronate should be used with caution in renal impairment (reduce dose in mild, avoid if moderate to severe). MONITORING: Serum phosphate, serum alkaline phosphatase and (if possible) urinary hydroxyproline should be measured before starting and at intervals of 3 months---consult product literature for further information. COUNSELLING: Avoid food for atleast 2 hours before and after oral treatment perticularly calcium-containing products e.g milk; also avoid iron and mineral supplements and antacids.