Rituximab (Rituximab)
Overview of Rituximab
Rituximab is a monoclonal antibody which causes lysis of B-lymphocytes. Rituximab is used for the treatment of chemotherapy-resistant advanced follicular lymphoma, breast cancer and for diffuse large B-cell non-hodgkin`s lymphoma in combination with other chemotherapy.
Indication of Rituximab
Rituximab is primarily indicated in conditions like Advanced follicular lymphoma(chemo resistant), Non-hodgkin's lymphoma, and can also be given in adjunctive therapy as an alternative drug of choice in Sedation with amnesia.
Contraindication of Rituximab
Rituximab is contraindicated in conditions like Breast feeding,Hypersensitivity to any component of product,Hypersensitivity to murine proteins.
Side Effects of Rituximab
The symptomatic adverse reactions produced by Rituximab are more or less tolerable and if they become severe, they can be treated symptomatically, these include Blood dyscrasias, Affectced liver function.
Precautions of Rituximab
Pregnancy. Rituximab should be used with caution in patients receiving cardiotoxic chemotherapy or with a history of cardiovascular disease because exacerbation of angina, arrhythmia, and heart failure have been reported. Transient hypotension occurs frequently during infusion and antihypertensives may need to be withheld for 12 hours before infusion.