Sirolimus (Sirolimus)
Overview of Sirolimus
Sirolimus is a potent non-calcineurin inhibiting immunosuppressant. Sirolimus is given after kidney transplant to keep body from rejecting the new kidney. It can cause hyperlipidemias. It has been shown to possess antifungal and antineoplastic properties. Sirolimus is often given in conjunction with cyclosporin.,Everolimus A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. Check for active clinical trials or closed clinical trials using this agent.
Indication of Sirolimus
Sirolimus is primarily indicated in conditions like Autoimmune disease, Rejection of organ transplants, and can also be given in adjunctive therapy as an alternative drug of choice in Prophylaxis of organ rejection in kidney allograft recipients.
Contraindication of Sirolimus
Sirolimus is contraindicated in conditions like Hypersensitivity to the drug.
Side Effects of Sirolimus
The severe or irreversible adverse effects of Sirolimus, which give rise to further complications include Blood disorders.,The symptomatic adverse reactions produced by Sirolimus are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Constipation, Abdominal pain, Nausea and vomiting, Hypersensitivity reactions, GI disturbance.
Precautions of Sirolimus
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. While you are taking sirolimus, it is important to maintain good dental hygiene and see a dentist regularly for teeth cleaning. Sirolimus may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take or have recently taken oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid other persons who have taken the oral polio vaccine. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.