Oxacillin (Oxacillin)
Overview of Oxacillin
Oxacillin is an isoxazolyl antistaphylococcal penicillin used similarly to fluclit. Oxacillin is mainly used in the treatment of infections caused by penicillinase-resistant strains of staphylococci, including bacteremia, skin and soft-tissue infections, respiratory tract infections, bone and joint infections, and urinary tract infections. It inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins (PBPs) that are located inside the bacterial cell wall. Like all ß-lactam antibiotics, its ability to interfere with PBP-mediated cell wall synthesis ultimately leads to cell lysis. It was approved by the FDA in 1962.
Indication of Oxacillin
Oxacillin is primarily indicated in conditions like Staphylococcal infections.
Contraindication of Oxacillin
Oxacillin is contraindicated in conditions like Allergy,Hypersensitivity to any component of product.
Side Effects of Oxacillin
The severe or irreversible adverse effects of Oxacillin, which give rise to further complications include Hepatitis, Cholestatic jaundice, Cholestatic jaundice, Neutropenia, Agranulocytosis.,Oxacillin produces potentially life-threatening effects which include Anaphylactic shock. which are responsible for the discontinuation of Oxacillin therapy.,The signs and symptoms that are produced after the acute overdosage of Oxacillin include Seizures, Skin rashes, Confusion, Behavioural changes.,The symptomatic adverse reactions produced by Oxacillin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Skin RashX, GI upset, Hypersensitivity reactions, Stomach pain, Vaginal Itching.
Precautions of Oxacillin
Elimination rate will be slow in neonates. Modify dosage in patients with renal impairment and in the elderly. Use with caution in patients with cephalosporin hypersensitivity.