Vasopressin (Vasopressin)
Overview of Vasopressin
The pressor and antidiuretic principle of the posterior lobe of the pituitary gland. It is prepared either by synthesis or by extraction from the glands of healthy domestic animals. It has a direct antidiuretic effects on the kidney, so it is used in the treatment of acute and chronic diabetes insipidus due to deficiency in antidiuretic hormone. It is administered IM, IV, SC or by nasal inhalation or topical application to the nasal mucosa.
Indication of Vasopressin
Vasopressin is primarily indicated in conditions like Bleeding from oesophageal varices, Diabetes insipidus, Pituitary diabetes insipidus.
Contraindication of Vasopressin
No data regarding the contra indications of Vasopressin is available.
Side Effects of Vasopressin
The severe or irreversible adverse effects of Vasopressin, which give rise to further complications include Cardiac arrhythmias, Bradycardia, Hypertension, Gangrene, Chest pain, Thrombosis.,Vasopressin produces potentially life-threatening effects which include Anaphylactic shock, Myocardial Ischemia, Cardiac Arrest. which are responsible for the discontinuation of Vasopressin therapy.,The symptomatic adverse reactions produced by Vasopressin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, Tremors, Sweating, Urticaria, Cramps, Nausea and vomiting, Hypersensitivity reactions, Pallor.
Precautions of Vasopressin
Avoid use in patients with chronic nephritis with nitrogen retension. It should be used with caution and in small doses in patients with vascular disease, especially of coronary arteries. It should be given with care to patients with asthma, migrane, epilepsy, heart failure or hypertension. Fluid retension should be adjusted to avoid hyponatremia.