Amrinone (Lactate) (Amrinone (Lactate))
Overview of Amrinone (Lactate)
Amrinone (Lactate) is a vasodilator with positive inotropic properties, belongs to phosphodisterase inhibitors. Amrinone (Lactate) is used for the short term management of heart failure unresponsive to other forms of therapy. The mechanism of action has not been fully determined , however it appears to involve an increase in cAMP concentration due to inhibition of phosphodisterase leading to an increased contractile force in cardiac muscle. Amrinone (Lactate) is given by intravenous route.
Indication of Amrinone (Lactate)
Amrinone (Lactate) is primarily indicated in conditions like Heart failure.
Contraindication of Amrinone (Lactate)
Amrinone (Lactate) is contraindicated in conditions like Hypersensitivity to the drug.
Side Effects of Amrinone (Lactate)
The severe or irreversible adverse effects of Amrinone (Lactate), which give rise to further complications include Cardiac arrhythmias, Hypotension, Hepatosplenomegaly, Hepatosplenomegaly.,The signs and symptoms that are produced after the acute overdosage of Amrinone (Lactate) include Thrombocytopenia.,The symptomatic adverse reactions produced by Amrinone (Lactate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fever, Local pain, Hypersensitivity reactions, Chest pain, GI disturbance, Nail discoloration.
Precautions of Amrinone (Lactate)
It should be used cautiously in severe obstructive aortic or pulmonary valvular disease or in hypertrophic cardiomyopathy. Blood pressure and heart rate should be monitored during parentral administration. The fluid and electrolyte balnace should be maintained. Platelet counts and liver function should also be monitored.