Enoximone (Enoximone)
Overview of Enoximone
Enoximone is a phosphodiesterase inhibitor similar to amrinone, with +ve ionotropic and vasodilator activity. Enoximone is administered intravenosly in the management of heart failure.
Indication of Enoximone
Enoximone is primarily indicated in conditions like Acute heart failure.
Contraindication of Enoximone
Enoximone is contraindicated in conditions like Epilepsy,Hypovolaemia.
Side Effects of Enoximone
The severe or irreversible adverse effects of Enoximone, which give rise to further complications include Hypotension, Hypotension, Tonic-clonic seizures, Arruthmia.,Enoximone produces potentially life-threatening effects which include Ventricular tachycardia. which are responsible for the discontinuation of Enoximone therapy.,The signs and symptoms that are produced after the acute overdosage of Enoximone include Hypotension, Ventricular, Arrhythmias.,The symptomatic adverse reactions produced by Enoximone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Fever, Abdominal pain, Chills, Local thrombophlebitis, Irritation, Sleep disturbance, Thrombocytopenia, Oliguria, Urinary retention, Pain in upper & lower extremities, Abnormal liver enzyme values.
Precautions of Enoximone
Blood pressure, heart rate, ECG, fliud and electrolyte status, platelet count and liver function should be monitored during therapy. It should be used with caution in patients with liver or renal disease, hypertrophic cardiomypathy or severe obstructive aortic or pulmonary valvular disease.