Eflornithine (Eflornithine)
Overview of Eflornithine
Eflornithine Hcl is an antiprotozoal agent. Eflornithine Hcl is used in the treatment of African trypanosomiasis and is effective in early and more importantly in late stages of this disease when there is CNS involvement. It acts as an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in the biosynthesis; trypanosomas are more susceptible yo the effect of eflornithine. It also has activity against Pneuocystis carinii.
Indication of Eflornithine
Eflornithine is primarily indicated in conditions like Meningoencephalitic intrypanosoma brucei infection, Sleeping sickness., Trypanosomiasis.
Contraindication of Eflornithine
Eflornithine is contraindicated in conditions like Hypersensitivity to the drug.
Side Effects of Eflornithine
The severe or irreversible adverse effects of Eflornithine, which give rise to further complications include Anemia, Anemia, Thrombocytopenia, Skin rashes, Leucopenia, Seizures, Irritation, Anemia, Anemia.,Eflornithine produces potentially life-threatening effects which include Cardiac Arrest, Cardiac arrest. which are responsible for the discontinuation of Eflornithine therapy.,The symptomatic adverse reactions produced by Eflornithine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Vomiting, Alopecia, Anorexia, Diarrhea, Abdominal pain, Asthenia, Facial edema, Folliculitis, Alopecia, dizziness.
Precautions of Eflornithine
It should be used with caution in patients with impaired renal function. Dose adjustment is necessary to compensate for reduced excretion of the drug. Other drugs should not be administeredduring infusion with eflornithine. Safety and effectiveness in children have not been established. Avoid Eflornithine getting in your eyes,nose or mouth. Donot wash treated areas for atleast 4 hours. Tell your doctor if you are allergic to it or if you ever had acne.