Glycopyrrolate (Glycopyrrolate)
Overview of Glycopyrrolate
Glycopyrrolate synthetic quaternary anticholinergic. Glycopyrrolate used in the treatment of peptic ulcers. Glycopyrrolate slows the activity of the stomach and intestinal tract. Glycopyrrolate relieves cramping and reduces acid secretion. Administerd orally, intramuscularly, subcutaneously and intravenously.,Glycopyrronium (Br) is a quaternary ammonium compound with antimuscarinic properties and peripheral actions similar to those of atropine. Glycopyrronium (Br) is given orally to reduce the intestinal motility and also is used parenterally to block the effects of parasympathetic stimulation during anaesthesia and surgical procedures.
Indication of Glycopyrrolate
Glycopyrrolate is primarily indicated in conditions like Anesthesia, Control of muscarinic side-effects of neostigmine, Drying secretions, Hyperacidity, Neuromuscular blockade, Premedication in anaesthesia, Reduction of excessive respiratory secretions (death rattle) in palliative care, Reversal of excessive bradycardia, Spasticity, Surgery, and can also be given in adjunctive therapy as an alternative drug of choice in Cardiac arrhythmia, Hyperhidrosis, Peptic ulcer.
Contraindication of Glycopyrrolate
Glycopyrrolate is contraindicated in conditions like Glucoma,Obstructive uropathy,Achalasia.
Side Effects of Glycopyrrolate
The severe or irreversible adverse effects of Glycopyrrolate, which give rise to further complications include Tachycardia, Tachycardia.,Glycopyrrolate produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Glycopyrrolate therapy.,The signs and symptoms that are produced after the acute overdosage of Glycopyrrolate include Seizures, Tachycardia, Dry mouth, Confusion, Hallucinations, Pyrexia, Delirium, Ataxia, Hyperpyrexia, Mydriasis, Hypertension, Incoordination, Nausea & vomiting, Dry skin.,The symptomatic adverse reactions produced by Glycopyrrolate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Tachycardia, Constipation, Blurred vision, Urinary retensionX, Dryness of mouth, Mental confusion, Taste disturbance, Nausea and vomiting.
Precautions of Glycopyrrolate
Closely monitor patients for therapeutic response and side effects of glycopyrrolate. It should not used in high doses because may produce mental depression and mental distrubances. It should be used with caution in patients over 40yrs. Because may increase the risk of glaucoma. It should be used with caution in patients with asthma, heart or kidney diseases. It should be used with caution in infants and small children. Should be used with caution in coronocy artery disease and uralemia.