Valsartan (Valsartan)
Overview of Valsartan
Valsartan belongs to a new and rapidly growing group of drugs known as angiotensin receptor antagonists. itsimilar to losartan. Valsartan antagonizes angiotensin II at the AT1 receptor subtype. Two angiotensin II receptors, AT1 and AT 2, have been identified. Angiotensin II is the primary vasoactive hormone of the renin-angiontensin system and plays an important role in the pathophysiology of hypertension and congestive heart failure. Valsartan is currently approved as an oral antihypertensive agent, either alone or in combination with other antihypertensive agents. Valsartan reduces left ventricular hypertrophy, although the clinical benefValsartan associated with reducing LV hypertrophy is not well established. Unlike losartan, Valsartan has no effect on serum uric acid. Valsartan was FDA approved for the treatment of hypertension on 23rd december 1996.
Indication of Valsartan
Valsartan is primarily indicated in conditions like Chronic congestive heart failure, Hypertension, Myocardial infarction.
Contraindication of Valsartan
No data regarding the contra indications of Valsartan is available.
Side Effects of Valsartan
The severe or irreversible adverse effects of Valsartan, which give rise to further complications include Hyperkalemia, Anemia, Angioedema, Azotemia.,The symptomatic adverse reactions produced by Valsartan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Abdominal pain, Cough.
Precautions of Valsartan
Valsartan should be used with caution in patients with any pre-existing kidney or liver disease, congestive heart failure, diabetes or any allergy, especially drug allergy. To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. It should be used caution while performing tasks requiring alertness, because this medication causes dizziness. Caution is advised when this drug is used in the elderly persons. It is not recommended for use during pregnancy or lactation.