Calcitriol (Calcitriol)
Overview of Calcitriol
Calcitriol is a 1, 25-dihydroxycholecalciferol (vitamin D), a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Vitamin D is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the 'sunshine vitamin' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Calcitriol is also found in certain food. Fish liver oils, especially code liver oil are good sources of vitamin D. Calcitriol has been used in the management of psoriasis.
Indication of Calcitriol
Calcitriol is primarily indicated in conditions like Hypocalcaemia, Hypophosphataemia, Oncogenic hypophosphatemic osteomalacia, Renal tubular osteomalacia, Sporadic hypophosphatemic osteomalacia, Uraemic osteodystrophy, Uremic osteodystrophy, Vitamin D-dependent rickets, and can also be given in adjunctive therapy as an alternative drug of choice in Neonatal hypocalcemia, Osteomalacia, Osteomalacia in malabsorption syndrome, Osteoporosis, Psoriasis, Rickets in premature infants, X-linked hypophosphataemic osteomalacia.
Contraindication of Calcitriol
Calcitriol is contraindicated in conditions like Hypercalcaemia.
Side Effects of Calcitriol
The severe or irreversible adverse effects of Calcitriol, which give rise to further complications include Urinary calcium stone formation, Urinary calcium stone formation.,Calcitriol produces potentially life-threatening effects which include Depression of CNS, Coma, Ectopic mineralization. which are responsible for the discontinuation of Calcitriol therapy.,The signs and symptoms that are produced after the acute overdosage of Calcitriol include Iatrogenic poisoning.
Precautions of Calcitriol
Evaluate Vit.D administration in fortified food, diet and drugs. It may be necessary to limit dietary Vit.D during treatment. If products of Vit.D contain tartrazine may cause allergic reaction (Including bronchial asthma) in susceptible individuals, Specially patients with aspirin hypersensitivity.