Paroxetine (Paroxetine)
Overview of Paroxetine
Paroxetine Hcl is antidepressant and belongs to selective serotonin reuptake inhibitors (SSRIs). Paroxetine Hcl is used to treat obsessive-compulsive disorders and panic disorders. Paroxetine Hcl is a phenylpiperidine derivative that is prepared by chemical synthesis. Paroxetine Hcl is optically active and the (-) nantiomer is used clinically. Paroxetine Hcl is not available in any combination preparations. Paroxetine Hcl is administered orally.
Indication of Paroxetine
Paroxetine is primarily indicated in conditions like Acute dystonia, Depression, Depression accompanied by anxiety, Depressive illness and post-traumatic stress disorder, Monotherapy (epilepsy), Obsessive-compulsive disorders, Panic disorders, Post traumatic stress disorder, Social phobia.
Contraindication of Paroxetine
Paroxetine is contraindicated in conditions like Epilepsy,Heart failure,Mania,Seizures,Hypersensitivity.
Side Effects of Paroxetine
The severe or irreversible adverse effects of Paroxetine, which give rise to further complications include Convulsions, Urticaria, Glaucoma, Impotence, Angioedema, Extrapyramidal symptoms, Myopathy, Mania, Tremors, Oro-facial dystonia, Galactorrhea.,The signs and symptoms that are produced after the acute overdosage of Paroxetine include Tachycardia, Coma, Dry mouth, Fever, Dilated pupils, Sweating, Irritability, Tremor, Nausea & vomiting, Somnolence, BP changes, Involuntary muscle contraction.,The symptomatic adverse reactions produced by Paroxetine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Weakness, Dizziness, Headache, Nausea, Vomiting, Anorexia, Diarrhea, Anxiety, Palpitation, Constipation, Insomnia, Nervousness, Sweating, Blurred vision, Urinary retensionX, Rashes, Confusion, Jaundice, Hallucination, Hypotension, Diaphoresis, Postural hypotension, Elevation of liver enzymes, Thrombocytopenia, SomnolenceX, Decrease in libido, Agitation, Taste disturbances, Ejaculatory failure, Increased intracranial pressure, Vasodilation, Dreams abnormality, Yawning, Xerostomia, Ejaculatory disturbances, Hyponatremia, Skin bleeding, Mucous membrane bleeding, Suicidal attempts, Myoclonus, Hyperreflexia.
Precautions of Paroxetine
Paroxetine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with pre-existing kidney disease, liver disease, seizure disorder, thyroid disease, history of substance abuse or if have any allergy, in patients with a history of mania, to patients receiving oral anticoaagulants, in cardiac patients, in epilepsy, narrow angle glaucoma, patients already receiving neuroleptics, patients treating with drugs that give an increase risk of bleeding and in patients with a known tendency for bleeding or those with predisposing conditions.