Moclobemide (Moclobemide)
Overview of Moclobemide
Moclobemide is oral antidepressant agent acts by selective inhibiton of monoamine oxidase type A in the brain. Increases brain monoamines by reducing their enzyme breakdown. Acts more rapidly than earlier MAOIs such as Phenelzine, and causes fewer side effects. Moclobemide is effective in the treatment of depression in patients who are allergic or untreated with tricyclic antidepressants.
Indication of Moclobemide
Moclobemide is primarily indicated in conditions like Autoimmune conditions, Depression, Social phobia.
Contraindication of Moclobemide
Moclobemide is contraindicated in conditions like Phaeochromocytoma,Thyrotoxicosis,Acute confusion states.
Side Effects of Moclobemide
The symptomatic adverse reactions produced by Moclobemide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Constipation, Insomnia, Confusion, Nausea and vomiting, Visual disturbances, Confusion, dizziness, parasthesia.
Precautions of Moclobemide
Patient should be closely monitored during early antidepressant therapy until improvement in depression is observed because suicide is an inherent risk in depressed patients. Moclobemide should be avoided in exited or agitated patients or those with severe hepatic (liver) impairment. Care should also required in patients with thyrotoxicosis as moclobemide may precipitate hypertensive reaction.