Bupivacaine Hcl (Bupivacaine Hcl)
Overview of Bupivacaine Hcl
Bupivacaine Hcl is amide local anesthetic and a homologue of mepivacaine, chemically related to lidocaine. It consists of an aromatic ring connected by an intermediate chain to an ionizable group, usually a tertiary amine. Bupivacaine Hcl is more potent and has a longer duration of action than mepivacaine.
Indication of Bupivacaine Hcl
Bupivacaine Hcl is primarily indicated in conditions like Epidural block, surgery, Heart failure, Labor, Local anaesthesia, Local infiltration, Peripheral nerve block, Supraventricular arrhythmias (particularly atrial fibrillation), Sympathetic block.
Contraindication of Bupivacaine Hcl
Bupivacaine (HCl) is contraindicated in conditions like Hypovolaemia,Intravenous regional anaesthesia,Hypersensitivity.
Side Effects of Bupivacaine Hcl
Bupivacaine (HCl) produces potentially life-threatening effects which include Respiratory depression, Respiratory arrest. which are responsible for the discontinuation of Bupivacaine (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Bupivacaine (HCl) include Metallic taste, Tinnitus, Anxiety, Irrational behavior, Circumoral numbness.,The symptomatic adverse reactions produced by Bupivacaine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Anxiety, Tinnitus, Metallic taste, Shivering, Circumoral numbness.
Precautions of Bupivacaine Hcl
Avoid Bupivacaine in patient with known hypersensitivity. It should be given with caution to the elderly, to debilitated, to children, patients with epilepsy, impaired cardiac conduction or respiratory function, shock or liver damage. It might be ototoxic and should not be instilled into the middle ear. The application of local anaesthatics to the skin for prolonged period or to the extensive area should be avoided.