Dorzolamide (Dorzolamide)
Overview of Dorzolamide
Dorzolamide Hcl reduces intraocular (eye) pressure and is used to treat glaucoma and elevated intraocular (eye) pressure. Dorzolamide and bringolamide both work by inhibiting earbonic cmhydrase (isoemynell which is found in the ciliary body epithelium. This reduce the formation of biearbonate ions, which recluces fluid transport and thus IOP. reduces IOP by reducing aqueous humar production. They are licensed for use in pateints resistant to beta-blokess or those in whom beta-blockess are contra-indicated. They are used alone or as an adjuant to a topical beta-blocker.
Indication of Dorzolamide
Dorzolamide is primarily indicated in conditions like Ocular hypertension, Open-angle glaucoma, Pseudoexfoliative glaucoma, Raised iop.
Contraindication of Dorzolamide
Dorzolamide is contraindicated in conditions like Renal impairment,Hyperchloremic acidosis.
Side Effects of Dorzolamide
The symptomatic adverse reactions produced by Dorzolamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Inflammation, Nausea, Urticaria, Burning, Asthenia, Lacrimation, Conjunctivitis, Photophobia, Ocular irritation, Vision disturbances, Tearing, Keratitis, Stinging, Local allergies, Xerophthalmia, Rarely hypersensitivity reactions.
Precautions of Dorzolamide
The preservative in this medication may be absorbed by soft contact lenses; therefore, it is recommended that soft contact lenses not be worn while using this medication. Dorzolamide should not be administered to patients with carbonic anhydrase inhibitor hypersensitivity. In addition, since dorzolamide is a sulfonamide derivative, it should not be used in patients with sulfonamide hypersensitivity. Topical administration of dorzolamide can result in systemic absorption. In sulfonamide-sensitive patients, administration of sulfonamides by any route can precipitate a possibly severe reaction. Its use as a single agent is insufficient for the management of closed-angle glaucoma. The use of multiple dose containers of ophthalmic products has been associated with bacterial keratitis. Inadvertent contamination of the product may occur if the patient has an ocular infection, or corneal abrasion. If there is any damage to the ocular epithelial surface dorzolamide should be used with caution. It should be used with caution in patients with hepatic disease. It is classified as pregnancy category C. Should be use during pregnancy only if the benefits outweigh the possible risks to the fetus. Cuation:- Systemic alesorption follows topical application; history of renal calculi; chronic corneal defects, history of intra-ocular surgury.