Clemastine (Clemastine)
Overview of Clemastine
Clemastine is antihistaminic agent. Chemically Clemastine is (+)-2-[2(p-chloro-a-methyl-a-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine. Clemastine is effective in providing relief from symptoms of allergies such as watery eyes, runny nose, itching and sneezing.
Indication of Clemastine
Clemastine is primarily indicated in conditions like Advanced ovarian cancer, Allegic rhinopathies, Hay fever, Insect bites, Rhinitis, Symptomatic relief of allergy, Urticaria, and can also be given in adjunctive therapy as an alternative drug of choice in Anaphylactic reactions, Angioneurotic edema, Dermatitis, Drug eruptions, Eczema.
Contraindication of Clemastine
Clemastine is contraindicated in conditions like Porphyria,Hypersensitivity.
Side Effects of Clemastine
The severe or irreversible adverse effects of Clemastine, which give rise to further complications include CNS stimulation.,The signs and symptoms that are produced after the acute overdosage of Clemastine include Seizures, Hyperthermia, Constipation, Dry mouth, Dilated pupils, postical depression, Nausea & vomiting.,The symptomatic adverse reactions produced by Clemastine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Nausea, Constipation, Dry mouth, Sedation, Skin rash, Gastralgia, Dry mouth.
Precautions of Clemastine
Clemastine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer subcutaneously because irritation or lesion may occur.