Triazolam (Triazolam)
Overview of Triazolam
Triazolam is oral benzodiazepine used as a hypnotic agent in the short-term management of insomnia. its structure includes the addition of a triazole ring at the 1, 2 position. A substituent in the 7th position such as halogen or a nitro group is required for its sedative-hypnotic activity.The benzodiazipines are more effective and safer. Benzodiazepines can produce any level of CNS depression required including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and coma. The action of these drugs is mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), potentiating the effects of GABA and increasing the inhibition of the ascending reticular activating system. Triazolam is often preferable to chlordiazepoxide, flurazepam, and prazepam in treating anxiety or insomnia, particularly in the elderly or patients with liver disease, because it has a relatively shorter half-life and does not generate active metabolites. It was approved by the FDA in 1982.
Indication of Triazolam
Triazolam is primarily indicated in conditions like Anxiety, Insomnia.
Contraindication of Triazolam
No data regarding the contra indications of Triazolam is available.
Side Effects of Triazolam
The severe or irreversible adverse effects of Triazolam, which give rise to further complications include Restlessness, Anxiety, Paranoia, Paresthesia, Unreality, Suicidal ideation, Altered sense of smell, Altered sense of taste, Hyperacusis.,Triazolam produces potentially life-threatening effects which include Intrahepatic cholestasis. which are responsible for the discontinuation of Triazolam therapy.,The symptomatic adverse reactions produced by Triazolam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Diarrhea, Palpitation, Skin rashesX, Nervousness, Dry mouth, Blurred vision, Pruritus, Epigastric pain, Hiccups, Burning eyes, Amnesia.
Precautions of Triazolam
Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Administer triazolam with caution in severely depressed patients. Limit repeated prescriptions without adequate medical supervision.