Tolbutamide (Tolbutamide)
Overview of Tolbutamide
Tolbutamide is a sulfonylurea compound. Tolbutamide is oral anti-diabetic agent, acts by increasing pancreatic insulin secretion. Tolbutamide is used in the treatment of non-insulin dependent diabetes. Tolbutamide is recommended when there is great danger of hypoglycemia (in elderly).
Indication of Tolbutamide
Tolbutamide is primarily indicated in conditions like NIDDM, Softening and dilatation of cervix before mechanical cervical dilatation.
Contraindication of Tolbutamide
Tolbutamide is contraindicated in conditions like Adrenal insufficiency,Thyroid disease,Renal diseases,Hepatic disease,Iddm,Diabetic ketoacidosis.
Side Effects of Tolbutamide
The severe or irreversible adverse effects of Tolbutamide, which give rise to further complications include Thrombocytopenia, Hyponatremia, Pancytopenia, Hepatosplenomegaly.,Tolbutamide produces potentially life-threatening effects which include Hypoglycemia, Hepatic dysfunction. which are responsible for the discontinuation of Tolbutamide therapy.,The signs and symptoms that are produced after the acute overdosage of Tolbutamide include Vomiting.,The symptomatic adverse reactions produced by Tolbutamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea and vomiting, Skin sensitization, Increased intracranial pressure.
Precautions of Tolbutamide
Tolbutamide should be used with caution in patients with high blood pressure or liver or kidney disease. This medication may make person more prone to sunburn, wear protective clothing and sunscreen. It should be used with extreme caution during pregnancy or lactation. Insulin therapy may be necessary during pregnancy.