Thioguanine (Thioguanine)
Overview of Thioguanine
Thioguanine is antineoplastic\anticancer drugs. Thioguanine is structural analogue of naturally occuring purine, guanine, both used by cells for DNA synrhesis. It belongs to a class of antimetabolite, with actions and uses similar to that of mercaptopurine. Antimetabolite are the compound that bear a structural similarity to a natutally occuring substance, such as vitamin, nucleoside or amino acid. Thioguanine is used chiefly in the treatment of lymphoblastic leukemia. Thioguanine is usually given in combination with other anticancer drugs to obtain better results and minimize side effects or toxicity. Thioguanine is administered orally. It was approved by FDA in 1966.
Indication of Thioguanine
Thioguanine is primarily indicated in conditions like Acute leukemia, Chronic myeloid leukaemia, Myeloblastic leukemia.
Contraindication of Thioguanine
No data regarding the contra indications of Thioguanine is available.
Side Effects of Thioguanine
The severe or irreversible adverse effects of Thioguanine, which give rise to further complications include Thrombocytopenia, Hepatotoxicity, Leucopenia, GI symptoms, Prolongation of clotting time, Anaemia.,Thioguanine produces potentially life-threatening effects which include Bone marrow suppression. which are responsible for the discontinuation of Thioguanine therapy.
Precautions of Thioguanine
Thioguanine is not recommended for use in pregnant or nursing women. Contraceptive (birth control) measures are recommended for use in men or women while taking this medication.