Terfenadine (Terfenadine)
Overview of Terfenadine
Terfenadine is a H1-antagonist antihistamine that is similar in structure to astemizole. it, however, has a much shorter duration of action. Unlike other H1-antagonists, therapeutic doses of it produce insignificant anticholinergic activity or sedation, perhaps due to poor penetration of the drug into the CNS. it blocks the effects of histamine on H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H1-receptors also suppresses the formation of edema, flare, and pruritus that result from histaminic activity. At higher concentrations, H1-receptor antagonism becomes relatively irreversible. Terfenadine is used to provide relief from symptoms of allergies such as rash, hives, watery eyes, runny nose, itching eyes and sneezing, also used in skin allergies such as urticaria.
Indication of Terfenadine
Terfenadine is primarily indicated in conditions like Advanced ovarian cancer, Allergy, Angioedema, Angiooedema, Asthma, Conjuctivitis, Dermatitis, Lung cancer, Rhinitis, Urticaria.
Contraindication of Terfenadine
No data regarding the contra indications of Terfenadine is available.
Side Effects of Terfenadine
The severe or irreversible adverse effects of Terfenadine, which give rise to further complications include Allergic hepatitis.,The signs and symptoms that are produced after the acute overdosage of Terfenadine include Convulsions, Ventricular arrhythmias.,The symptomatic adverse reactions produced by Terfenadine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Fatigue, Alopecia, Photosensitivity, Burning, Depression, Angioedema, Desquamation.
Precautions of Terfenadine
Terfenadine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer S/C because irritation or lesion may occur.