Sulphinpyrazone (Sulphinpyrazone)
Overview of Sulphinpyrazone
Sulphinpyrazone is a sulfoxide analogue of phenylbutazone. Sulphinpyrazone is used as an uricosuric agent. Sulphinpyrazone is organic acid and act at the anionic transport sites of the renal tubule. Sulphinpyrazone is employed to decrease the body pool of urate in patients with tophaceous gout or in those with frequent gouty attacks. Sulphinpyrazone is not used for acute attacks of gout. It has been studied as an antithrombotic agent.
Indication of Sulphinpyrazone
Sulphinpyrazone is primarily indicated in conditions like Gout prophylaxis, Infertility without hyperprolactinaemia, Mild to moderate endometriosis.
Contraindication of Sulphinpyrazone
Sulphinpyrazone is contraindicated in conditions like Gout,Peptic ulcer,Renal failure,Nephrolithiasis,Hepatic disease.
Side Effects of Sulphinpyrazone
The severe or irreversible adverse effects of Sulphinpyrazone, which give rise to further complications include Hematuria, Renal colic, Bleeding from pre-existing ulcer disease.,Sulphinpyrazone produces potentially life-threatening effects which include Blood dyscrasias. which are responsible for the discontinuation of Sulphinpyrazone therapy.,The symptomatic adverse reactions produced by Sulphinpyrazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Skin rashes, Epigastric discomfort.
Precautions of Sulphinpyrazone
Sulphinpyrazone should be used only when clearly needed during pregnancy or lactation. Avoid alcohol while taking this drug.