Stilboestrol (Stilboestrol)
Overview of Stilboestrol
Stilboestrol is a synthetic hormone. Stilboestrol is used as a contraceptive. Stilboestrol is used to treat symptoms associated with menopause. It may also be used to prevent osteoporosis (bone loss), amenorrhea, abnormal uterine bleeding and to inhibit growth of prostate and breast cancer
Indication of Stilboestrol
Stilboestrol is primarily indicated in conditions like Adjunct in the treatment of opiod dependence, Oncology, Prostatic cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Breast cancer, Prostate cancer.
Contraindication of Stilboestrol
Stilboestrol is contraindicated in conditions like Hypertension,Vaginal bleeding,Sickle cell anaemia,Porphyrias,Thromboembolism,Premenopausal breast cancer.
Side Effects of Stilboestrol
The severe or irreversible adverse effects of Stilboestrol, which give rise to further complications include Impotence, Testicular atrophy, Thromboembolic disorder, Thrombosis.,Stilboestrol produces potentially life-threatening effects which include Hepatotoxicity, Thromboembolic disease. which are responsible for the discontinuation of Stilboestrol therapy.,The signs and symptoms that are produced after the acute overdosage of Stilboestrol include Nausea & vomiting.,The symptomatic adverse reactions produced by Stilboestrol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nipple tenderness, Nausea and vomiting, Breast discomfort, Breast enlargement.
Precautions of Stilboestrol
High doses of estrogen used in treatment of malignant disease should be used cautiously in patients with cerebrovascular disorder, cardiovascular disease, coronary artery disease, venous thromboembolism or liver impairment. Estrogens should be used with caution in children, because premature closure of epiphysis may occur resulting in inhibited linear growth and small stature. Slow infusion is not recommended, because cytotoxic concentration of drug is not achieved. It is not recommended for use during pregnancy.