Pyrazinamide (Pyrazinamide)
Overview of Pyrazinamide
Pyrazinamide is antituberculosis agent. Pyrazinamide is the pyrazine analogue of nicotinamide. Pyrazinamide is stable and quite inexpensive. It may be bacteriostatic or bacteriocidal against Mycobacterium tuberculosis depending on the concentration of drug attained at the site of infection. Resistance to drug emerges rapidly when the drug is used alone. Therefore Pyrazinamide is always given in combination with other antituberculosis drug.
Indication of Pyrazinamide
Pyrazinamide is primarily indicated in conditions like Acute leukemia, Tuberculosis (with other anti-tuberculosis drugs), and can also be given in adjunctive therapy as an alternative drug of choice in Tuberculosis.
Contraindication of Pyrazinamide
Pyrazinamide is contraindicated in conditions like Renal diseases,Hepatic disease.
Side Effects of Pyrazinamide
The severe or irreversible adverse effects of Pyrazinamide, which give rise to further complications include Sideroblastic anemia, Precipitation of gout.,Pyrazinamide produces potentially life-threatening effects which include Hepatitis, Hyperbilirubinemia. which are responsible for the discontinuation of Pyrazinamide therapy.,The symptomatic adverse reactions produced by Pyrazinamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Anorexia, Fever, Malaise, Arthralgia, Nausea and vomiting.
Precautions of Pyrazinamide
Pyrazinamide should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any pre-existing kidney disease, liver disease, gout, diabetes or if have any allergy.