Propylthiouracil (Propylthiouracil)
Overview of Propylthiouracil
Propylthiouracil used in treatment of hyperthyroidism (overactive thyroid gland). Propylthiouracil decreases the formation of thyroid hormone from thyroid gland.
Indication of Propylthiouracil
Propylthiouracil is primarily indicated in conditions like Hyperthyroidism, Thyrotoxicosis.
Contraindication of Propylthiouracil
Propylthiouracil is contraindicated in conditions like Hepatitis,Agranulocytosis,Vasculitis.
Side Effects of Propylthiouracil
Propylthiouracil produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia, Aplastic Anemia, Hepatitis, Leucopenia, LE-like syndrome, Vasculitis. which are responsible for the discontinuation of Propylthiouracil therapy.,The signs and symptoms that are produced after the acute overdosage of Propylthiouracil include Vomiting, Fever, Epigastric pain, Arthralgia, Pruritus, Pancytopenia.,The symptomatic adverse reactions produced by Propylthiouracil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Maculopapular rash, Urticaria.
Precautions of Propylthiouracil
Excessive dose of antithyroid should not be used, because it may cause hypothyroidism or goiter. Treatment should be discontinued immediately if there is any clinical or lab evidence of neutropenia. It is not recommended to use high dose during pregnancy or lactation. Before having an emergency treatment or surgery including dental surgery, tell the doctor about the use of the drug. Propylthiouracil should be use with caution in patients with blood disease.