Prazosin (Prazosin)
Overview of Prazosin
Prazosin is a piperazinyl quinazoline derivative, is a selective competitive a1 receptor blocking similar to the other alpha I -antagonists doxazosin and terazosin, both of which are longer acting than it. Prazosin is given orally for the management of hypertension. It also has been used in the treatment of heart failure; however, due to the development of tolerance, Prazosin is seldom used for this condition today. It was approved by the FDA in 1976.
Indication of Prazosin
Prazosin is primarily indicated in conditions like Congestive heart failure, Dissolution of gallstones, Hypertension, Infertility or irregular cycles, Raynaud's phenomenon, and can also be given in adjunctive therapy as an alternative drug of choice in Raynaud`s syndrome.
Contraindication of Prazosin
No data regarding the contra indications of Prazosin is available.
Side Effects of Prazosin
The severe or irreversible adverse effects of Prazosin, which give rise to further complications include Palpitation, Dizziness, Loss of consciousness.,Prazosin produces potentially life-threatening effects which include Hypotension. which are responsible for the discontinuation of Prazosin therapy.,The signs and symptoms that are produced after the acute overdosage of Prazosin include Drowsiness, Depression.,The symptomatic adverse reactions produced by Prazosin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Orthostatic hypotension.
Precautions of Prazosin
To avoid first dose effect i.e. marked postural hypotension and syncope, initial dose of prazocin should be reduced and to be taken at the bedtime.