Phentolamine (Mesylate) (Phentolamine (Mesylate))
Overview of Phentolamine (Mesylate)
Phentolamine (Mesylate) is alpha-adrenoceptor blocking drug with partial agonist and smooth muscle relaxant activity . Phentolamine (Mesylate) is used in the management of hypertension associated with pheochromocytoma, also used as a diagnostic test.
Indication of Phentolamine (Mesylate)
Phentolamine Mesylate is primarily indicated in conditions like Hypertension, Impotency, Phaeochromocytoma, Prophylaxis of NSAID-induced ulcer, and can also be given in adjunctive therapy as an alternative drug of choice in Skin necrosis.
Contraindication of Phentolamine (Mesylate)
Phentolamine (Mesylate) is contraindicated in conditions like Hypotension,Obstructive cardiomyopathy,Cardiovascular disease,Cerebrovascular disease,Aortic stenosis.
Side Effects of Phentolamine (Mesylate)
Phentolamine (Mesylate) produces potentially life-threatening effects which include Hypotension. which are responsible for the discontinuation of Phentolamine (Mesylate) therapy.,The signs and symptoms that are produced after the acute overdosage of Phentolamine (Mesylate) include Hypotension, Tachycardia, Cardiac arrhythmias, Hypoglycemia, Sweating, Headache, Excitation, Visual distrubances.,The symptomatic adverse reactions produced by Phentolamine (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Nausea and vomiting.
Precautions of Phentolamine (Mesylate)
Phentolamine should not be given to patients with angina pectoris, ischaemic heart disease. Care should be taken in patients with peptic ulcer disease.