Phenindione (Phenindione)
Overview of Phenindione
Phenindione is a prothrombopenic anticoagulant drug with same action and uses as for dicumarol. Chemically Phenindione is 2-phenyl-1, 3-indandione. It has rapid onset of action and short duration of action. The actions are erratic and its short-duration of action is of little theraoeutic advantage.
Indication of Phenindione
Phenindione is primarily indicated in conditions like Deep vein thrombosis, Prevention of embolism, Prevention of thrombosis, Prophylaxis after insertion of prosthetic heart valve, Prophylaxis and treatment of venous thrombosis and pulmonary embolism, Prophylaxis of embolisation in rheumatic heart disease and atrial fibrillation, Pulmonary embolism, and can also be given in adjunctive therapy as an alternative drug of choice in Rheumatic heart disease.
Contraindication of Phenindione
No data regarding the contra indications of Phenindione is available.
Side Effects of Phenindione
The severe or irreversible adverse effects of Phenindione, which give rise to further complications include Fever, Skin rashes, Hypersensitivity reactions, Renal impairment, Skin necrosis.,Phenindione produces potentially life-threatening effects which include Blood dyscrasias, Bleeding, Hepatitis. which are responsible for the discontinuation of Phenindione therapy.,The symptomatic adverse reactions produced by Phenindione are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Skin reactions.
Precautions of Phenindione
Phenindione should be used with caution in patients with ulcers, unusual menstrual periods, diabetes, liver or kidney disease, high blood pressure, arthritis, thyroid problems, all recent infections, if have had recent surgery or of drug and food allergies. If patient have an illness that causes vomiting, diarrhea or fever for more than a few days, contact the doctor as these problems can change the effect of drug. Limit consumption of alcoholic beverages. Avoid sudden changes in dietary habits. Avoid ingesting unusual increases or decreases of foods high in Vitamin K (e.g.liver, cauliflower, cabbage, spinach and other green leafy vegetables, green tea, certain vegetables, cheeses and certain vitamin supplements). It is best to avoid strictly vegetarian diets that consist of foods high in vitamin K.Be extra careful to avoid injuries, because this medication can cause heavy bleeding. Be careful while brushing teeth and use an electric razor. It should not be used during pregnancy or lactation.