Nabumetone (Nabumetone)
Overview of Nabumetone
Nabumetone is a nonsteroidal anti-inflammatory drug. Chemically Nabumetone is identified as 4-( 6-methoxy-2-naphthalenyl)-2-butanone. Nabumetone is given by mouth in osteoarthritis and rheumatoid arthritis. The drug itself is a relatively weak inhibitor of prostaglandin synthesis, but Nabumetone is metabolized in the liver to a more active compound. May thus cause less gastro-intestinal irritation than some other drugs in this class such as indomethacin, but is still contraindicated if there is a history of peptic ulceration.
Indication of Nabumetone
Nabumetone is primarily indicated in conditions like Endometrial thinning before intra-uterine surgery, Osteoarthritis, Pain, Pain and inflammation in rheumatoid arthritis, Rheumatoid arthritis, and can also be given in adjunctive therapy as an alternative drug of choice in Ankylosing spondylitis, Soft tissue rheumatism.
Contraindication of Nabumetone
Nabumetone is contraindicated in conditions like Peptic ulcer.
Side Effects of Nabumetone
The severe or irreversible adverse effects of Nabumetone, which give rise to further complications include Cholestatic jaundice, Complications of GI ulcerations.,The symptomatic adverse reactions produced by Nabumetone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Nausea, Diarrhea, Abdominal pain, Increased intracranial pressure.
Precautions of Nabumetone
Nabumetone should be used with caution in patients with any liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease or allergies, especially drug allergies. It should be used with caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication and make stomach or intestines more likely to bleed. Caution is advised when this drug is used in the elderly. This medication should be used during pregnancy or lactation only if clearly needed. Use of this drug in the last 6 months of pregnancy is not recommended.