Mifepristone (Mifepristone)
Overview of Mifepristone
Mifepristone is a synthetic progesterone antagonist, related to norethindrone. Chemically Mifepristone is identified as (11ß,17ß)-11-[ 4-(dimethylaminoamino) phenyl ]-17-hydroxy-17-(1-propynyl) estra-4, 9-dien-3-one. Mifepristone is used orally for termination of pregnancy up to 9 weeks gestation.it should be used only in centres licensed under the abortion act. If abortion is not complete after 36-48 hrs, treatment with gemeprost should be given surgical abortionmay be used if drug treatment fails.
Indication of Mifepristone
Mifepristone is primarily indicated in conditions like Abortion, Contraception, Cushing's syndrome, Hypothyroid coma, Induction of labour, Menstruation disorders, Muscle spasm of varied aeitology, Routine management of the 3rd stage of labour, Severe nausea and vomiting (prevention), Softening and dilatation of cervix before mechanical cervical dilatation, Termination of pregnancy of 13-24 weeks gestation.
Contraindication of Mifepristone
No data regarding the contra indications of Mifepristone is available.
Side Effects of Mifepristone
The severe or irreversible adverse effects of Mifepristone, which give rise to further complications include Hypotension, Hypotension, Hypersensitivity reactions.,The symptomatic adverse reactions produced by Mifepristone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fever, Chills, Malaise, Heavy bleeding, dizziness, Urtercaria, GI craps.
Precautions of Mifepristone
Mifepristone should not be given to patients with chronic adrenal failure, haemorrhagic disorders or those receiving anticoagulants or long term corticosteroid therapy, impaired liver or kidney function. It should be used with caution in patients with chronic obstructive air way disease, asthma or cardiovascular disease. It is not recommended to use during pregnancy.