Metyrapone (Metyrapone)
Overview of Metyrapone
Metyrapone is inhibitor of 11b-hydroxylase, an important cytochrome P450 enzyme involved in the biosynthesis of cortisol and alsosterone. Metyrapone is administered orally. Metyrapone is used in the treatment of cushing's syndrome. Metyrapone is also used in tests of pituitary gland function..
Indication of Metyrapone
Metyrapone is primarily indicated in conditions like Adrenal failure, Cushing's syndrome, Differential diagnosis of acth-dependent cushing`s syndrome, Edema, Management of cushing`s syndrome, Oedema, Resistant oedema, and can also be given in adjunctive therapy as an alternative drug of choice in Hypersensitivity, Lactation, Porphyria, Pregnancy.
Contraindication of Metyrapone
Metyrapone is contraindicated in conditions like Adrenal insufficiency.
Side Effects of Metyrapone
The severe or irreversible adverse effects of Metyrapone, which give rise to further complications include Alopecia, Bone marrow depression.,The signs and symptoms that are produced after the acute overdosage of Metyrapone include Convulsions, Unconsciousness, Cardiac arrest, Extensor spasm of fingers, Glucocorticoid insufficiency.,The symptomatic adverse reactions produced by Metyrapone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Abdominal pain, Sedation, Hypotension, Nausea and vomiting, Hypertension, dizziness, Allergic, Hypoadrenalism.
Precautions of Metyrapone
Metyrapone should be used only if clearly needed during pregnancy. It should be used with caution in patients with any pre-existing thyroid disorder or any allergy or hepatic impairment.