Metformin Hcl (Metformin Hcl)
Overview of Metformin Hcl
Metformin Hcl is oral biguanide antidiabetic agent, introduced in 1950s. It reduces elevated blood glucose concentration in diabetic patients, but it does not increase insulin secretion. Metformin Hcl is used alone or in combination with insulin or chlorpropamide. Most useful in overweight subjects, where it supresses appetite. May cause nausea, vomiting and diarrhoea.
Indication of Metformin Hcl
Metformin Hcl is primarily indicated in conditions like Diabetes mellitus, Hyperlipoproteinaemia, Insulin dependent diabetes mellitus, Insulin resistance, Non-insulin dependent diabetes mellitus, Obesity.
Contraindication of Metformin Hcl
Metformin (HCl) is contraindicated in conditions like Alcohol dependence,Anaemia,Myocardial infarction,Septicaemia,Infections,Respiratory disease,Ketosis,Cardiovascular disease,Diabetic coma,Trauma,Iron deficiency,Vitamin B12 deficiency,Renal impairment,Diabetic retinopathy,Liver damage.
Side Effects of Metformin Hcl
The severe or irreversible adverse effects of Metformin (HCl), which give rise to further complications include Vasculitis, Pneumonitis, Malabsorption of vit B12, Malabsorpton of folic acid, Megaloblastic anemia, Hypoglycemia.,Metformin (HCl) produces potentially life-threatening effects which include Lactic Acidosis. which are responsible for the discontinuation of Metformin (HCl) therapy.,The symptomatic adverse reactions produced by Metformin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Flatulence, Nausea, Vomiting, Anorexia, Diarrhea, Skin reactions, Weight LossX, Hypersensitivity, Metallic taste.
Precautions of Metformin Hcl
Metformin should be used with caution in patients with pre-existing liver disease, kidney disease, heart trouble or if have any allergy, infections. Avoid excessive use of alcohol while taking this. It is not recommended for use during pregnancy and should be used only if clearly needed during lactation.