Mesna (Mesna)
Overview of Mesna
Mesna is a detoxifying agent. Mesna is used to protect bladder mucosa from the irritant effect of ifosfamide or cyclophosphamide (anticancer drugs), acts by combining with thier toxic metabolite acrolein but does not prevent thier other toxic effects. Chemically Mesna is identified as sodium 2-mercaptoethane sulfonate. It also has mucolytic properties. It also has a mucolytic activity. Mesna is available for oral and intravenous administration.
Indication of Mesna
Mesna is primarily indicated in conditions like Cyclophosphamide induced hemorrhagic cystitis, Ifosfamide induced hemorrhagic cystitis, Prostate cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Cancer.
Contraindication of Mesna
Mesna is contraindicated in conditions like Hypersensitivity.
Side Effects of Mesna
The signs and symptoms that are produced after the acute overdosage of Mesna include Diarrhea, Convulsions, Headache, Tremor.,The symptomatic adverse reactions produced by Mesna are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, Tachycardia, Abdominal pain, Hypotension, Cough, Bronchospasm, Limb pain, Joint pain, Exhaustion, Yellowing of teeth.
Precautions of Mesna
Mesna should be avoided if possible during pregnancy or lactation. It should be used with caution in patients with any pre-existing illness or any allergy.