Aurothiomalate (Aurothiomalate)
Overview of Aurothiomalate
Aurothiomalate is a parentrally administered preparation of Gold. Gold compounds were introduced for the treatment of rheumatoid arthritis in the 1920s. Aurothiomalate is administered intramuscularly as water soluble gold salt containing 50 % elemental gold. Gold therapy is indicated for active rheumatoid arthritis.
Indication of Aurothiomalate
Aurothiomalate is primarily indicated in conditions like Juvenile chronic arthritis, Palindromic rheumatism, Psoriatic arthritis, Rheumatoid arthritis.
Contraindication of Aurothiomalate
Aurothiomalate is contraindicated in conditions like Bone marrow depression,Nephritis.
Side Effects of Aurothiomalate
The severe or irreversible adverse effects of Aurothiomalate, which give rise to further complications include Renal damage, Thrombocytopenia, Musculoskeletal effects.,Aurothiomalate produces potentially life-threatening effects which include Bone marrow aplasia, Neutropenia, Pancytopenia. which are responsible for the discontinuation of Aurothiomalate therapy.,The signs and symptoms that are produced after the acute overdosage of Aurothiomalate include Nausea, Vomiting, Erythematous rash, Exfoliative dermatitis, Stomatitis, Pharyngitis, Tracheitis, Gastritis, Colitis, Vaginitis, BLood dyscrasias, Albuminuria, Hematuria, Acute renal failure, Encephalitis, Polyneuropathy, Jaundice.,The symptomatic adverse reactions produced by Aurothiomalate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Mouth ulcers, Skin RashX.
Precautions of Aurothiomalate
Do not use Penicillamine or antimalarial with gold salts such as aurothiomalate. Before initiating treatment rule out pregnancy, perform complete blood count, urine analysis, liver and renal function test. Use with caution in patients with compromised cardiovascular or cerebral circulation.