Mecillinam (Mecillinam)
Overview of Mecillinam
Mecillinam is a derivative of amidinopenicillanic acid. Unlike benzylpenicillin and related antibiotics, Mecillinam is active against many Gram -ve bacteria in perticular Enterobacteriaceae including Escherichia coli, Enterobacter, Klebsiella, Salmonella and Shigella spp.; Mecillinam is less active against Neisseria spp. and Haemophilus influenzae. It interferes with the synthesis of the bacterial cell wall by binding with a different penicillin-binding protein from benzylpenicillin. Mecillinam is inactivated by beta-lactamases, but is more stable than ampicillin.
Indication of Mecillinam
Mecillinam is primarily indicated in conditions like Bacterial infections, Enteric fever, UTI.
Contraindication of Mecillinam
Mecillinam is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects of Mecillinam
The symptomatic adverse reactions produced by Mecillinam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Vaginitis, Thrombophlebitis.
Precautions of Mecillinam
It should not be given in case of hypersensitivity to penicillins.