Atracurium Besylate (Atracurium Besylate)
Overview of Atracurium Besylate
The first drug that was found capable of blocking the skeletal neuromuscular junction was curare, which the native hunters of the Amazon in the South America used to paralyze prey. Atracurium is a skeletal muscle relaxant and structural analog of acetylcholine. Atracurium (Besylate) is iso-quinoline non-depolarizing competitive neuromuscular blocking agent. The neuromuscular blocking agents have significantly increased the safety of anesthesia , since less anesthetic is required to produce muscle relaxation.
Indication of Atracurium Besylate
Atracurium (Besylate) is primarily indicated in conditions like Adjunct to anesthesia, Muscle relaxation, Muscle relaxation during intensive care, Muscle relaxation for surgery or intubation, Neuromuscular blockade.
Contraindication of Atracurium Besylate
Atracurium (Besylate) is contraindicated in conditions like Hypersensitivity.
Side Effects of Atracurium Besylate
Atracurium (Besylate) produces potentially life-threatening effects which include Anaphylactic reactions. which are responsible for the discontinuation of Atracurium (Besylate) therapy.,The signs and symptoms that are produced after the acute overdosage of Atracurium (Besylate) include Respiratory muscle paralysis.,The symptomatic adverse reactions produced by Atracurium (Besylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Histamine release, Bradycardia, Wheezing, Reaction at injection site.
Precautions of Atracurium Besylate
Exercise special caution, especially when histamine release would be hazardous, especially in patients with significant cardiovascular diseases. Use atracurium with caution in patients with bronchial asthma.