Isradipine (Isradipine)
Overview of Isradipine
Isradipine is a calcium-channel blocking agent of the dihydropyridine class similar to nifedipine, amlodipine, and felodipine. On a miligram-per-miligram basis, Isradipine is the mostpotent drug ?? of this class of drug.it was approved by the FDA in December 1990 for the treatment of hypertension. The mechanism of action is similar to other calcium-channel antagonists, acts by inhibiting the influx of extracellular calcium across the cell membrane of myocardial and vascular smooth muscle. The serum calcium levels remain unchanged. it increases myocardial oxygen supply (secondary to coronary vasodilation) and also decreases myocardial oxygen demand (secondary to decreased afterload and lack of an increase in heart rate). These effects seem to best explain the benefit of it and other dihydropyridines in the treatment of angina. It also causes vasodilation in coronary, skeletal, and cerebral vasculature.
Indication of Isradipine
Isradipine is primarily indicated in conditions like Angina, Hypertension, Recent myocardial infarction.
Contraindication of Isradipine
Isradipine is contraindicated in conditions like Heart failure,Aortic stenosis,Sinus node disease.
Side Effects of Isradipine
The severe or irreversible adverse effects of Isradipine, which give rise to further complications include Sinus tachycardia, Hypotension, Hypotension, Angina, Bradyarrhythmias.,Isradipine produces potentially life-threatening effects which include Heart failure. which are responsible for the discontinuation of Isradipine therapy.,The signs and symptoms that are produced after the acute overdosage of Isradipine include Hypotension.,The symptomatic adverse reactions produced by Isradipine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Dyspnea, Palpitation, Tachycardia, Skin rashes, Peripheral edema, Pruritus, Malaise, Weight gain, Flushing, Polyuria, Abdominal discomfort, Gingival hyperplasia, Skin rashes, dizziness.
Precautions of Isradipine
Isradipine should be used only if clearly needed during pregnancy. It should be used with caution in patients with pre-existing heart disease, history heart arrhythmias, liver disease, kidney disease or blood disorders. Acautious dosage regimen is recommended for pateints with hepatic dysfunction, chronic heart failure,& elderly.