Iopanoic Acid (Iopanoic Acid)
Overview of Iopanoic Acid
Iopanoic Acid is iodinated radiographic contrast medium that after oral administration is absorbed from the deudenum, conjugated with glucoronic acid in the liver and secreted in bile. Iopanoic Acid is used as a radiopaque medium in cholecystography and for oral cholangiograghy.
Indication of Iopanoic Acid
Iopanoic Acid is primarily indicated in conditions like Cholecystography, Epilepsy (monotherapy), Radiological contrast agent, Vestibular disorders, and can also be given in adjunctive therapy as an alternative drug of choice in Hyperthyroidism.
Contraindication of Iopanoic Acid
Iopanoic Acid is contraindicated in conditions like Cardiovascular disease,Malabsorption.
Side Effects of Iopanoic Acid
The severe or irreversible adverse effects of Iopanoic Acid, which give rise to further complications include Thrombocytopenia, Renal impairment, Thyrotoxicosis, Urate nephropathy, Hepatic impairment.,Iopanoic Acid produces potentially life-threatening effects which include Anaphylactoid reactions, Coronary insufficiency, Cardiovascular collapse. which are responsible for the discontinuation of Iopanoic Acid therapy.,The signs and symptoms that are produced after the acute overdosage of Iopanoic Acid include Diarrhea, Nausea & vomiting.,The symptomatic adverse reactions produced by Iopanoic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Abdominal pain, Rashes, Urticaria, Pruritus, Dysuria, Cramps, Nausea and vomiting, Heart burn, Hypersensitivity reactions, Sore throat, dizziness.
Precautions of Iopanoic Acid
Avoid use of iopanoic acid in patients with severe renal (kidney) or hepatic (liver) disease. Dose higher than 3gm should not be given to patients with renal impairment. Avoid use in presence of acute gastro-intestinal disease, as it may impair the absorption. It should be used with caution in patients with history of hypersensitivity to iodine, or other contrast media, hyperthyroidism, hyperuricaemia.