Ibuprofen (Ibuprofen)
Overview of Ibuprofen
Ibuprofen is a non-steroidal analgesic, antipyretic and antinflammatory agent. It was the first propionic acid derivative to be used in most countries. Chemically Ibuprofen is (+/-)2-(4-Isobutylphenyl) propionic acid. It reduces inflammation, fever and relieves pain. Ibuprofen is equivalent to aspirin in its antinflammatory effects, but Ibuprofen is more effective analgesic than aspirin or acetaminophen. Ibuprofen is prepared chemically and marketed as racemic mixture of its two enantiomers. Ibuprofen is available in combination with codeine, acetaminophen ans pseudoephedrine. Ibuprofen is available for oral and topical administration.
Indication of Ibuprofen
Ibuprofen is primarily indicated in conditions like Cystic fibrosis, Fever, Juvenile chronic arthritis, Migraine, Mild to moderate pain, Musculoskeletal pain, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Post operative analgesia, Rheumatoid arthritis, Severe pain and tenderness in benign fibrocystic breast disease, Toothache, and can also be given in adjunctive therapy as an alternative drug of choice in Acute arthritis, Ankylosing spondylitis, Dysmenorrhoea, Inflammatory bowel disease.
Contraindication of Ibuprofen
Ibuprofen is contraindicated in conditions like Hypertension,Peptic ulcer,Bronchospasm,Renal failure,Hypersensitivity,GI bleeding.
Side Effects of Ibuprofen
The severe or irreversible adverse effects of Ibuprofen, which give rise to further complications include Thrombocytopenia, Elevated blood pressure.,Ibuprofen produces potentially life-threatening effects which include Vomiting, Peptic ulceration, Hematemesis, Severe gastric pain. which are responsible for the discontinuation of Ibuprofen therapy.,The signs and symptoms that are produced after the acute overdosage of Ibuprofen include Hypotension, Nausea, Vomiting, Cardiac arrhythmias, Coma, Seizures, Acidosis, Ataxia, Headache, Renal failure, Epigastric pain, Tinnitus, Tinnitus, Hyperkalemia, GI bleeding, Renal and Hepatic dysfunction.,The symptomatic adverse reactions produced by Ibuprofen are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Diarrhea, Constipation, Tinnitus, Blurred vision, Rashes, Urticaria, Pruritus, Gastritis, Depression, Elevation of liver enzymes, Fluid retention, Edema, SomnolenceX, Hearing loss, Hypersensitivity reactions, Blood dyscrasias, Angioedema, Vision disturbances, Aseptic maningitis, dizziness.
Precautions of Ibuprofen
Ibuprofen should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing uncontrolled infection. Perform periodic auditory (hearing) function test during chronic therapy. Discontinue drug if skin reaction occurred.