Hydralazine Hcl (Hydralazine Hcl)
Overview of Hydralazine Hcl
Hydralazine is antihypertensive agent. It acts as a vasodilator. It relaxes and expands blood vessels and lowers the blood pressure. It also function as antioxidant. It has been available for many years, though it was initially thought not to be particularly effective because tachyphylaxis to hypertensive effects developed rapidly. Now the benefits of combination therapy are recognized, and may be used more effectively particularly in severe hypertension.
Indication of Hydralazine Hcl
Hydralazine Hcl is primarily indicated in conditions like Benign gastric and duodenal ulcers, Heart failure, Hypertension, Hypertension with renal complications and hypertensive crisis (including during pregnancy), Hypertensive emergencies, Moderate to severe hypertension, Moderate to severe hypertension (adjunct), Primary pulmonary hypertension, Severe or recurrent duodenal and gastric ulcertion, and can also be given in adjunctive therapy as an alternative drug of choice in Heart failure (with long acting nitrate).
Contraindication of Hydralazine Hcl
Hydralazine (HCl) is contraindicated in conditions like Angina,Rheumatic mitral valvular heart disease,Hypersensitivity.
Side Effects of Hydralazine Hcl
The severe or irreversible adverse effects of Hydralazine (HCl), which give rise to further complications include Tachycardia, Lupus erythematosus, Hydralazine lupus, Peripheral neuritis, Tachycardia.,The signs and symptoms that are produced after the acute overdosage of Hydralazine (HCl) include Coma, Tachycardia, Dysarthria.,The symptomatic adverse reactions produced by Hydralazine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Headache, Diarrhea, Palpitation, Impotence, Flushing, Tremor, Nausea and vomiting, Muscle cramps, Edema, Micturition, Chest pain, Lacrimation, Loss of appetite, angina pectoris.
Precautions of Hydralazine Hcl
Hydralazine should be used with caution in patients with coronary artery disease, cerebrovascular disease, severe renal (kidney) damage. Monitor complete blood count at baseline & periodically during therapy. Take Hydralazine with meals or snacks. Avoid alcohol as it may worsen its side effects. Cautions should be taken if you ever had coronary artery disease or a heart attack. Donot stop this drug suddenly as it cause your blood pressure to become dangerously high.Drug induced lupus like syndrome Ou large doses &l long duration.